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KMID : 0369819960260040257
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Jorunal of Korean Pharmaceutical Sciences
1996 Volume.26 No. 4 p.257 ~ p.261
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A Study on the Solubilization and Physical Properties of Sanjoinine-A
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서광교/Sheu KG
이치호/Lee CH
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Abstract
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The seeds of Zizyphus Jujuba have been used as an antianxiety agent for the treatment of insomnia from the earliest times. Sanjoinine-A, isolated from the seeds of Zizyphus Jujuba, have been found to have a minor tranquilizer activity. However this drug is poorly soluble in water. In order to increase the dissolution rate of sanjoinine-A, solid dispersions with PVP-MC and inclusion complex with β?cyclodextrin were prepared and evaluated. All of these systems increased the dissolution rate of sanjoinine A comparing with sanjoinine-A free base. From pH-rate profile of sanjoinine-A at 60?C, it was found that sanjoinine A was relatively stable in acidic solution, but unstable in basic solution.
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KEYWORD
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Sanjoinine-A, Cyclodextrin, Inclusion complex, pH-rate profile
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